NewsLocal NewsAssisted suicide for ill people is ‘slippery slope’By admin – January 22, 2012 546 A REVIEW of laws which would allow doctors to assist seriously ill patients to die could lead to people who cannot make the decision for themselves being euthanised, a Limerick TD has warned. At a recent conference in Cork, Dr Adam McCauley, senior lecturer in medical and international human rights law in UCD, said that Irish law relating assisted suicide should be reviewed. Dr McCauley claimed that people with serious medical conditions are taking their lives “behind closed doors,” and sometimes with the assistance of medical practitioners.Sign up for the weekly Limerick Post newsletter Sign Up He was speaking in the wake of the publication of British report which describes current law on assisted suicide as “inadequate and incoherent”.But Fine Gael Deputy, Dan Neville, said that any liberalisation of the law on assisted death or euthanasia could have serious consequences.“It has been the experience elsewhere when euthanasia is legalised under very specific circumstances that although the criteria may be set tightly at the start, those criteria tend to loosen over time and a more liberal approach to euthanasia is taken”.Deputy Neville, who is president of the Irish Association of Suicidology, fears that older people who are ill and those severely handicapped, who do not have their full faculties, may be open to suggestion and pressure.“If someone is very ill or suffering from a disease such as Alzheimer’s, you have to ask whether they have the mental capacity to make a decision to end their own lives”.The British Commission on Assisted Dying recommended in it’s report, published last week, that a person who has a severe condition and less than a year to live, should be allowed to ask medical practitioners to assist them to die.But Deputy Neville said that this would constitute “a slippery slope.It started out tightly controlled in places like the Netherlands but that has all changed. There is a documented case recently of a woman in her fifties, who tragically lost both of her sons and she was considered a fit case for assisted suicide, even though she was in good physical health. And suicide rates generally increase in countries where euthanasia has been legalised. The attitude to all suicides changes”. Advertisement Email WhatsApp Linkedin Print Previous articleUnfinished estates may escape chargeNext articleBookmaker tells family ‘too late at starting gate’ for Euro draw admin Facebook Twitter
Custom genotyping arrays provide a flexible and accurate means of genotyping single nucleotide polymorphisms (SNPs) in a large number of individuals of essentially any organism. However, validation rates, defined as the proportion of putative SNPs that are verified to be polymorphic in a population, are often very low. A number of potential causes of assay failure have been identified, but none have been explored systematically. In particular, as SNPs are often developed from transcriptomes, parameters relating to the genomic context are rarely taken into account. Here, we assembled a draft Antarctic fur seal (Arctocephalus gazella) genome (assembly size: 2.41Gb; scaffold/contig N50: 3.1Mb/27.5kb). We then used this resource to map the probe sequences of 144 putative SNPs genotyped in 480 individuals. The number of probe-to-genome mappings and alignment length together explained almost a third of the variation in validation success, indicating that sequence uniqueness and proximity to intron-exon boundaries play an important role. The same pattern was found after mapping the probe sequences to the Walrus and Weddell seal genomes, suggesting that the genomes of species divergent by as much as 23 million years can hold information relevant to SNP validation outcomes. Additionally, re-analysis of genotyping data from seven previous studies found the same two variables to be significantly associated with SNP validation success across a variety of taxa. Finally, our study reveals considerable scope for validation rates to be improved, either by simply filtering for SNPs whose flanking sequences align uniquely and completely to a reference genome, or through predictive modeling.