1. Bottom trawl surveys on the South Georgia shelf indicate episodic declines in the abundance of the mackerel icefish Champsocephalus gunnari that, since 1990, are not directly attributable to commercial fishing. 2. The greatest effect has been observed in years when krill are known to have been scarce on the South Georgia shelf. 3. It is thought that C. gunnari survivorship is closely related to, but indirectly influenced by, krill availability. 4. Examination of food chain relationships indicates that predation by fur seals is likely to play a major role in the observed changes in C. gunnari abundance. 5. Periodic shifts in food chain relationships, involving krill, C. gunnari and fur seals, are postulated that could explain the episodic declines in the abundance of C. gunnari in the absence of fishing. 6. The study demonstrates how a key predator can have an over-riding impact on a commercial fish species, highlighting the importance of the ecosystem approach to fisheries management.
We report on the electric field variations during Saharan dust advection over two atmospheric remote stations in Greece, using synergistic observations of the vertical atmospheric electric field strength (Ez) at ground level and the lidar-derived particle backscatter coefficient profiles. Both parameters were monitored for the first time with the simultaneous deployment of a ground-based field mill electrometer and a multi-wavelength polarization lidar. The field mill time series are processed to extract the diurnal variations of the global electric circuit and remove fast field perturbations due to peak lightning activity. In order to identify the influence of the elevated dust layers on the ground Ez, we extract a localized reference electric field from the time series that reflects the local fair-weather activity. Then, we compare it with the reconstructed daily average behaviour of the electric field and the Saharan dust layers’ evolution, as depicted by the lidar. The observed enhancement of the vertical electric field (up to ∼100 V m−1), for detached pure dust layers, suggests the presence of in-layer electric charges. Although higher dust loads are expected to result in such an electric field enhancement, episodic cases that reduce the electric field are also observed (up to ∼60 V m−1). To quantitatively approach our results, we examine the dependency of Ez against theoretical assumptions for the distribution of separated charges within the electrified dust layer. Electrically neutral dust is approximated by atmospheric conductivity reduction, while charge separation areas within electrically active dust layers are approximated as finite-extent cylinders. This physical approximation constitutes a more realistic description of the distribution of charges, as opposed to infinite-extent geometries, and allows for analytical solutions of the electric field strength so that observed variations during the monitored dust outbreaks can be explained.
“LEFT JAB AND RIGHT JAB” FOOTNOTE: Any comments posted in this column do not represent the views or opinions of the City-County Observer or our advertisers.,“Right Jab And Left Jab” was created because we have two commenters that post on a daily basis either in our “IS IT TRUE” or “Readers Forum” columns concerning National or International issues.Joe Biden and Ronald Reagan’s comments are mostly about issues of national interest. The majority of our “IS IT TRUE” columns are about local or state issues, so we have decided to give Mr. Biden and Mr. Reagan exclusive access to our newly created “LEFT JAB and RIGHT JAB” column. They now have this post to exclusively discuss national or world issues that they feel passionate about.We shall be posting the “LEFT JAB” AND “RIGHT JAB” several times a week. Oh, “Left Jab” is a liberal view and the “Right Jab is representative of the more conservative views. Also, any reader who would like to react to the written comments of the two gentlemen is free to do so.,“Right Jab And Left Jab” was created because we have two commenters that post on a daily basis either in our “IS IT TRUE” or “Readers Forum” columns concerning National or International issues.Joe Biden and Ronald Reagan’s comments are mostly about issues of national interest. The majority of our “IS IT TRUE” columns are about local or state issues, so we have decided to give Mr. Biden and Mr. Reagan exclusive access to our newly created “LEFT JAB and RIGHT JAB” column. They now have this post to exclusively discuss national or world issues that they feel passionate about.We shall be posting the “LEFT JAB” AND “RIGHT JAB” several times a week. Oh, “Left Jab” is a liberal view and the “Right Jab is representative of the more conservative views. Also, any reader who would like to react to the written comments of the two gentlemen is free to do so. “Right Jab And Left Jab” was created because we have two commenters that post on a daily basis either in our “IS IT TRUE” or “Readers Forum” columns concerning National or International issues.Joe Biden and Ronald Reagan’s comments are mostly about issues of national interest. The majority of our “IS IT TRUE” columns are about local or state issues, so we have decided to give Mr. Biden and Mr. Reagan exclusive access to our newly created “LEFT JAB and RIGHT JAB” column. They now have this post to exclusively discuss national or world issues that they feel passionate about.We shall be posting the “LEFT JAB” AND “RIGHT JAB” several times a week. Oh, “Left Jab” is a liberal view and the “Right Jab is representative of the more conservative views. Also, any reader who would like to react to the written comments of the two gentlemen is free to do so. FacebookTwitterCopy LinkEmail,“LEFT JAB AND RIGHT JAB” FOOTNOTE: Any comments posted in this column do not represent the views or opinions of the City-County Observer or our advertisers. “Right Jab And Left Jab” was created because we have two commenters that post on a daily basis either in our “IS IT TRUE” or “Readers Forum” columns concerning National or International issues.Joe Biden and Ronald Reagan’s comments are mostly about issues of national interest. The majority of our “IS IT TRUE” columns are about local or state issues, so we have decided to give Mr. Biden and Mr. Reagan exclusive access to our newly created “LEFT JAB and RIGHT JAB” column. They now have this post to exclusively discuss national or world issues that they feel passionate about.We shall be posting the “LEFT JAB” AND “RIGHT JAB” several times a week. Oh, “Left Jab” is a liberal view and the “Right Jab is representative of the more conservative views. Also, any reader who would like to react to the written comments of the two gentlemen is free to do so.
North-west bakery chain Sayers the Bakers has bought a new bakery venture to the high street in the form of the Poundbakery.Although this project has remained relatively under the radar, Poundbakery has ramped up a massive 27 outlets over the past few months according to the bakery’s website located across the north west, including Bolton, Liverpool, Preston and Manchester.A spokesperson for the bakery said it was currently opening shops at the rate of a couple a week, and was due to open its 30th store, in Bolton, later this month.As the name suggests, the outlets sell a range of products, including sausage rolls, bread and cakes for £1 or less, under its strapline, ’Tasty Baking at Tasty Prices’.Consumers can purchase two meat and potato pies for £1, hot drinks for 50p, and fresh sandwiches and filled barms for £1 each, for example.
Robert Walter’s 20th Congress | State Theatre | Portland, ME | 2/2/19 | Photos: Vic Brazen On Saturday night, Umphrey’s McGee wrapped their brief northeast run with support from Robert Walter’s 20th Congress at Portland, ME’s State Theatre.Umphrey’s sandwiched their first set of the night with an opening “Cemetary Walk I” and a set-closing “Cemetary Walk II”. In between, they worked in extended renditions of “Syncopated Strangers” and “Remind Me”, a short-and-sweet “Nemo”, and rocking “Great American”.As “Great American” fizzled out, Brendan Bayliss noted, “We’re gonna bring up our good friend Scott Metzger for this next one. We don’t get to see him that much, so we gotta make it count when we do.” Metzger, who has been playing with 20th Congress on their current run of dates, then came up to help the band rock a cover of Talking Heads‘ “Girlfriend Is Better”, marking the first Umphrey’s McGee rendition of the song since 3/1/17. Following their setbreak, the band once again started a song sandwich that would last throughout the second set and encore. “Bridgeless” got the ball rolling before improv-heavy renditions of “It Doesn’t Matter” and “Ringo” kept the energy in the historic theatre high. From there, the band moved into “Phil’s Farm” and, in turn, dipped into “Seasons” before returning to “Phil’s Farm” to close set two. Finally, the band returned for their encore with “The Weight Around” before crashing back into “Bridgeless” to complete the musical thought they had begun with the set two opener.Below, you can check out a gallery of photos from Robert Walter’s 20th Congress and Umphrey’s McGee’s performances courtesy of photographer Vic Brazen.Umphrey’s McGee’s ongoing Wax On, Wax Off Tour continues this week with a three-night run at Brooklyn Steel in Brooklyn, NY on February 14th, 15th, and 16th. For a full list of upcoming Umphrey’s McGee shows, head to the band’s website.Setlist: Umphrey’s McGee | State Theatre | Portland, ME | 2/2/19Set One: Cemetary Walk I, Syncopated Stranger, Remind Me, Nemo, Great American > Girlfriend Is Better* > Cemetary Walk IISet Two: Bridgeless > It Doesn’t Matter, Ringo, Phil’s Farm > Seasons > Phil’s FarmEncore: The Weight Around > Bridgeless*with Scott MetzgerYou can stream full soundboard audio of the performance via Nugs.net.Umphrey’s McGee | State Theatre | Portland, ME | 2/2/19 | Photos: Vic Brazen Load remaining images Load remaining images
Designed to target skin cancer, implantable vaccine opens door to treating many cancers, inflammatory diseases Cancer vaccine begins Phase I clinical trials Personal cancer vaccines show promise Tumor-specific peptides could help eradicate tumors and prevent them from recurring Cancer vaccine success Implant-based cancer vaccine is first to eliminate tumors in mice Related Unlike cell-based cancer immunotherapies that manipulate immune cells outside of the body and transferring them into patients, the implantable immuno-material approach activates endogenous immune cells inside a patient’s own body to launch an attack on his or her cancer. The novel technique was developed, incubated, and advanced at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) by David Mooney, Wyss core faculty member, leader of the Immuno-Materials initiative at the Wyss Institute, and Robert P. Pinkas Family Professor of Bioengineering at SEAS.Made of the polymer that’s used in biodegradable sutures, this aspirin-sized device is designed to deliver immunotherapy agents that activate the immune system against tumors. Image courtesy of the Wyss Institute at Harvard UniversityThe Wyss Institute and SEAS announced Tuesday that Novartis will have access to commercially develop their therapeutic, biomaterial-based cancer vaccine technology that promotes cancer immunity. Under a licensing agreement spearheaded by Harvard’s Office of Technology Development (OTD), Novartis will have worldwide rights, in target-limited applications, to develop and translate this treatment approach.The first-generation therapy consists of a porous scaffold made from a widely used biodegradable medical polymer infused with inactivated antigens from the patient’s own tumor cells, as well as immunostimulatory molecules that attract dendritic cells of the immune system to the immuno-material site and activate them to stimulate a host response. Once activated, the dendritic cells move to nearby lymph nodes to orchestrate anti-tumor responses throughout the body.“This work resulted from a remarkable cross-disciplinary effort using the combined expertise of bioengineers, cancer biologists, and immunologists,” said Mooney. “We have demonstrated that these biomaterials can be easily delivered to patients, provide sustained and local release of immune-modulating factors, and bypass the need for modification of cells outside the body. This concept has led to a very promising platform for cancer immunotherapy.”,In 2013, the Wyss Institute and the Dana-Farber Cancer Institute (DFCI) initiated a Phase I clinical trial at DFCI to test the safety of the first of these implantable, immuno-material-based vaccines in patients with melanoma, a lethal form of skin cancer. The trial, led by F. Stephen Hodi Jr., director of DFCI’s Melanoma Center and professor of medicine at Harvard Medical School, is still ongoing with many of its original patients.The trial followed extensive preclinical studies by a collaborative team headed by Mooney and Glenn Dranoff, who at the time was a Wyss Institute associate faculty member and co-leader of Dana Farber’s Cancer Vaccine Center. The team demonstrated that the vaccine could potentially shrink or eradicate multiple types of tumors, in addition to acting as a prophylactic, in various animal models. Dranoff is now global head of exploratory immuno-oncology at the Novartis Institutes for Biomedical Research. Novartis has also established a collaboration agreement with the Wyss Institute to further develop biomaterial systems for its portfolio of second-generation immuno-oncology therapies.“When we initiated this cancer vaccine program at the Wyss Institute, it was strike zone for what we wanted to pursue — a research project conceived by our visionary faculty that was high-risk and required a highly collaborative and interdisciplinary effort but had the potential to bring about a transformative advance in clinical care,” said Wyss Institute Director Donald Ingber, the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children’s Hospital, as well as professor of Bioengineering at SEAS.“Then, with the vision and collaborative support of another institutional member of the Wyss Institute consortium, the Dana-Farber Cancer Institute, we made the decision to co-fund a Phase I clinical trial inside academia, which was really pushing the envelope. Thus, this agreement is extremely exciting for us because it validates our innovation model, but even more importantly, it will bring an exciting new therapeutic modality into the clinic for patients with many different types of cancer.”In addition to Mooney, Dranoff, and Hodi, other collaborators include Wyss senior staff scientist Edward Doherty, Wyss Institute staff scientist Omar Ali, DFCI Executive Director Jerome Ritz, Dana-Farber surgeons Sara Russell and Charles Yoon, Wyss Institute scientist Alexander Stafford, and other Wyss Institute researchers and clinical research team members at Dana-Farber.The development and study of the cancer vaccine was funded by the Wyss Institute, DFCI, and the National Institutes of Health. The licensed technologies are owned or co-owned by Harvard University, DFCI, and the University of Michigan.
By Dialogo April 20, 2011 Colombian President Juan Manuel Santos affirmed on 18 April that the country is in the final phase of the fight for peace, and it is therefore urgent that government forces redouble their efforts and multiply the number of actions in order to achieve that victory. “In every war, the final phase is the most complicated, the most difficult, and we’re in that final phase,” the president said at the Management Dialogues event held at the Defense Ministry. The head of state reaffirmed his confidence in the Armed Forces and invited their members to continue pressing forward, since “the challenge is a large one.” He highlighted Colombians’ backing for the work performed by members of government forces. He declared that “the work that is being done here in the ministry depends on that, and so does the fact that our heroes (because I’ve always considered them that way, our heroes), our soldiers, our police officers, our marines are all over our national territory, risking their lives; the achievement of that goal is going to depend on them. It’s a goal that the entire country supports,” he said. He affirmed that the ministry’s objectives are ambitious, but he indicated that he is sure that they will be met, because he had the opportunity to get to know the capabilities of the military as defense minister. “I remember very well that when I arrived at this ministry, we proposed to strike telling blows at the FARC secretariat, and people laughed: that’s what all the ministers have been saying for the last forty years. Well, thanks to your work, we’ve succeeded in striking the heaviest blows that have been struck against these FARC bandits in history,” he added. He reiterated that security is one of the national government’s priorities, as a fundamental starting point for prosperity. “We consider the work being done by the Ministry of Defense to be the most important of all. Security, as I’ve repeated on many, many occasions, is the foundation of progress. The Romans themselves, when they invented the republic, said that security is the republic’s first law. If that law is not enforced, the others become toothless,” President Santos indicated.
121SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Stuart R. Levine Founded in 1996, Stuart Levine & Associates LLC is an international strategic planning and leadership development company with focus on adding member value by strengthening corporate culture.SL&A … Web: www.Stuartlevine.com Details What are the values of your organization? Do you value teamwork or integrity or efficiency? More importantly, do your employees espouse the same values as you, as each other? What is your corporate culture? Do your employees fit into this culture? Do you? Should you care?The answers to these questions are more important to the bottom line than you may suspect. A corporate culture — your company’s prevailing ideas, values, attitudes, and beliefs that guide the way your employees think, feel, and act — has a profound effect on positive outcomes and financial performance.A 2014 study, “Parsing Organizational Culture: How the Norm for Adaptability Influences the Relationship Between Culture Consensus and Financial Performance in High-Technology Firms,” by Jennifer A. Chatman, David F. Caldwell, Charles A. O’Reilly and Bernadette Dower concluded that corporations with a strong positive culture performed better financially over a volatile three-year period than those companies with weaker cultures. Experts have suggested that the best way to maintain a positive culture with consistent values is to hire employees that will fit into an organization’s current culture. Employees that possess similar values and beliefs as others in the organization, and therefore are a good cultural fit, are more likely to stay with the company longer. When people don’t fit, they should not be selected for employment. If they are selected, they are often uncomfortable and either leave on their own or are terminated for behavioral reasons. The cost of turnover is astounding. Experts estimate that it costs between 1.5 and 3 times the annual salary for every new hire. That’s between $75,000 and $150,000 for a $50,000 employee. With costs like that, poor hires can significantly cut into corporate profits. We therefore need to ensure that new hires will be successful in our organization by carefully focusing on the hiring process.In order to hire employees to embrace the corporate values and fit into the culture, an organization must first know what their values and culture are. This is not as easy as a simple survey or scanning a company’s website to find its mission and values statement. If values and culture are not systematically and strategically created, they will evolve on their own, sometimes with devastating consequences (as in the case of Enron in the late 90’s). Leadership must profess the desired values and demonstrate them on a daily basis. Once the values are established, an organization can use them to create good hiring practices.Using structured or behavioral based interviews is paramount in good hiring practices. In order for this to be successful, however, the organization must have a clearly defined set of values. Once these are established, interview questions can be constructed to elicit descriptions of previous behaviors exhibited in specific situations, thus exploring candidates’ individual values. Instead of a subjective interview question such as, “tell me what you value” or “ what is your leadership style?” which tell you nothing about the candidate, questions such as, “tell me about a time when you were leading a team and one of your subordinates didn’t agree with your course of action” can elicit a much more descriptive response that can give you insight into your candidates value system. Structured interviewing has been proven effective in highly successful organizations such as Disney, Google and Southwest Airlines.But do we want to create a Stepford Wives of the workplace? If you hire people just like yourself, you wind up with a lot of people like you in the organization. You may replicate your strengths, but you will also replicate your weaknesses and not bring any new strengths into the company to augment your existing talents. Although we want to hire those that possess our corporate value system in order to strengthen our culture, diversity in thinking is extremely important for an organization’s success. Without it, we are doomed to “group think” and lose our ability for creative problem solving, thus putting our organization at a devastating strategic disadvantage.Good leadership is paramount in creating a values system that drives a positive corporate culture, while simultaneously creating diversity of thought and a culture of innovation. That balance is a key to success in today’s business organizations.
continue reading » Millennials get a bad rep just about everywhere. If you’re a Millennial on your credit union or bank’s leadership team, then you’re well aware of the uphill battle you fought to get there, and the even greater battles ahead.But let me remind you: Steve Jobs was 21 when he started Apple. Jeff Bezos was 30 when he started Amazon. Howard Schultz was 32 when he took over Starbucks.My point? Almost every business leader in history has been where you are. Even your board and executive team were once rookies.You can’t control your generation’s pre-existing reputation. You can’t control what your board and executive team think about “those young people.”What you can control, however, is your response. ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
“The organization is currently notifying anyone who has had known contact with the players, including recent opponents, and is working closely with state and local health authorities on reporting,” the team said.”All players and members of the Nets travel party are being asked to remain isolated, closely monitor their health and maintain constant communication with team medical staff.”The team last played against the Lakers in Los Angeles on March 10. A day later, the league suspended its season until further notice, as the coronavirus pandemic upended major sporting events across the globe.Topics : Four Brooklyn Nets players tested positive for coronavirus, the team confirmed on Tuesday, less than a week after the global outbreak prompted the suspension of the NBA season.Three of the players were asymptomatic while one was showing symptoms of the rapidly-spreading virus, days after the Utah Jazz reported that two of their players had also tested positive.The Nets said in a written statement that all four players were isolated and under the care of team physicians, but did not identify the individuals.